• NEWS . 29 Jun 2020
  • Potential of Netrin-1 as a diagnostic biomarker for ACS

  • Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis and ischaemia-reperfusion damage; however, to date there are no human studies about its role in acute coronary syndrome (ACS).

    In a prospective study, researchers included 188 patients with ACS and 50 healthy subjects without any disease at the emergency unit, and had their Netrin-1 levels examined. The aim of the study was to investigate Netrin-1 levels in the early diagnosis and successful reperfusion of ACS. 

    Results showed that the Netrin-1 levels of the patient group were substantively higher than the control group (p<0.001), and that the levels measured at initial admission (1.53±0.19) and after angiography (1.49±0.19) were statistically significant (p=0.049). After achievement of Thrombolysis in Myocardial Infarction (TIMI) 3 flow with angiography, Netrin-1 levels were detected to be low (p=0.039). Additionally, the levels obtained at the time of admission were determined to be significantly different between the Global Registry of Acute Coronary Events (GRACE) moderate and high-risk groups and the low-risk group (p=0.017).

    To conclude, Netrin-1 was shown to increase in the early diagnosis of ACS and to decrease in patients for whom reperfusion was established after angiography. Therefore, Netrin-1 can serve as an important biomarker as an indicator of diagnosis and successful reperfusion in ACS.

    Reference:
    Mutlu H, et al. Effect of serum netrin-1 levels on diagnosis and prognosis in patients admitted to the emergency service for acute coronary syndrome. Cureus 2020;12:e7741.