• NEWS . 22 Jun 2020
  • Smoking associated with higher severity of coronary lesions in young and middle-aged women

  • Smoking is significantly associated with an increased risk of extensive and severe coronary lesions among young and middle-aged female patients with acute coronary syndrome (ACS), according to data derived from the Improving Care for Cardiovascular Disease in China (CCC)-ACS project. The CCC-ACS project was a collaborative study of the Chinese Society of Cardiology and the American Heart Association that started in 2014, and has consecutively enrolled inpatients with ACS from 158 tertiary hospitals and 82 secondary hospitals across China. 

    This study comprised 2,863 female patients aged <60 years who received coronary angiography. The smoker group represented 12% (340 patients) of the total population; a higher proportion of this group were <45 years old (13.2% [45/340] vs 8.5% (215/2,523); p<0.01), and had a significantly lower prevalence of hypertension and diabetes. 

    However, prevalence of ST-elevation myocardial infarction, coronary multivessel lesions, and severe stenosis, either single-vessel or multivessel, was significantly higher in the smoker group than in the non-smoker group. Additionally, multivariate logistic regression analyses showed that after adjusting for factors like age and renal insufficiency, smokers faced a higher risk of coronary multivessel lesions, coronary multivessel severe lesions and coronary severe lesions (odds ratios [95% confidence interval]: 1.41 [1.11¬–1.79]; 1.40 [1.10–1.78] and 1.78 [1.11–2.87)], respectively) than non-smokers.

    Findings from this study underscore the dangers of smoking and the need to strengthen tobacco control education and smoking cessation guidance for young and middle-aged women.

    Hu GL, et al. Association between smoking and the severity of coronary lesions among young and middle-aged female patients with acute coronary syndrome. Zhonghua Xin Xue Guan Bing Za Zhi 2020;48:378–385.